An update of the research studies that we have been supporting with our LC-MS/MS assays
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Author(s)
Mira V. Doig and Colin Feyerabend
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| Presenter(s) |
Mira V. Doig Technical Director, ABS Laboratories Ltd., Welwyn Garden City |
Abstract Cotinine is a metabolite of nicotine and its presence in biological fluids indicates nicotine intake. Colin Feyerabend has been supporting smoking research since the 1970s. We still support passive smoking research by measuring cotinine in saliva and trends from the Health Survey of England since 1998 will be presented. We will also summarise the findings from a recent study that has investigated lung development in children and the effects of passive smoking.
The validation of smoking cessation using cotinine alone is becoming increasing difficult with the massive expansion of the use of E-Cigs and over-the-counter NRT. In this situation measuring anabasine and cotinine in saliva has proved to be very useful as the presence of anabasine indicates that any cotinine levels present has come from tobacco rather than E-Cigs or NRT. The analysis of anabasine and cotinine in saliva samples now enables stop smoking advisors to help with the treatment of their patients as they know whether they are cheating or not! Summaries of some of the studies we have supported with these assays will be presented.
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Presenter biography Mira V. Doig BSc PhD F. Chrom. Soc.
Mira joined forces with Dr Colin Feyerabend at ABS Laboratories in 1996 after 15 years supporting drug discovery and development at a Pharmaceutical Company, Wellcome, now part of GSK. Her expertise is developing LC-MS/MS and GC-MS assays for drugs, metabolites and biomarkers in biological fluids. Mira has worked hard with Colin to use these sophisticated technologies to supply cost effective assays to support smoking research and cessation programmes.
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Source of funding: ABS Laboratories
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Declaration of interest: The work has been funded by the government or charitable organisations or ABS Laboratories. There is conflict of interest.
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